This was totally within the realms of possibility for a poorly characterised "complementary medicine" product and should give real cause for concern if they claim that risk is linked to dosage.
Reason: they don't know what is in their product. It's not a drug comprised of one characterised compound, but a crude extract of literally thousands of different compounds from a plant that makes a bewildering array of specialised metabolites. Why does this matter? Changes in growing conditions due to environmental factors or farmer actions may considerably alter the composition of chemicals in each batch of product, and Promisia has no meaningful way of monitoring this. In reality, the dosage of active ingredients probably changes with every batch, and the plant is not even grown locally (mostly in India). Just one of *many* problems I have with this outfit. Please don't bring up the published studies - a critical eye can see that they are barely passable and the authors had to work to get the statistics in line.
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